大阳城集团娱乐网站539
个人简介
李传友，博士，中国科学院遗传与发育生物学研究所研究员，山东农业大学园艺科学与工程学院教授，博士生导师。
1999年获中国科学院遗传研究所博士学位。1999-2003年在Michigan State University DOE-Plant Research Laboratory从事博士后研究。2003年入选中国科学院“百人计划”，2004年获 “国家杰出青年科学基金”资助。2015年入选山东省首批泰山学者优势特色学科人才团队领军人才。2016年入选中组部“万人计划”科技创新领军人才。
教育教学工作
承担遗传学、生命科学进展等课程。
科学研究工作
研究方向：番茄优质抗逆的遗传调控与品种培育
1. 植物系统性防御机理的解码与操控。解析植物面对瞬息万变的机械伤害适时激活并恰当终止系统性防御的机理，提出打破高产高抗负相关的路线图；
2. 植物再生因子的发现与应用。破解植物为何具有动物不可比拟的器官再生能力，鉴定再生因子，建立不受基因型限制的转基因和基因编辑体系；
3. 优质抗病虫番茄的分子设计。针对优质和抗性难以兼顾的难题，解析品质和抗性关键基因互作机理，提出优质多抗番茄品种分子设计路线图。
科研简介：（项目、论文、专利、获奖等情况）
1999年获中国科学院遗传研究所博士学位。1999-2003年在Michigan State University DOE-Plant Research Laboratory从事博士后研究。2003年入选中国科学院“百人计划”，2004年获 “国家杰出青年科学基金”资助。2015年入选山东省首批泰山学者优势特色学科人才团队领军人才。2016年入选中组部“万人计划”科技创新领军人才。
曾担任国家重大科学研究计划项目首席科学家, 主要学术兼职包括《Molecular Plant》、《Horticulture Research》、《Plant Molecular Biology》等国际著名刊物编委。作为执行委员会委员和中方联络人组织实施了国际茄科基因组计划，完成了栽培番茄与其起源种醋栗番茄基因组的精细序列分析。作为学术秘书和执行主席组织召开了第286次香山科学会议“植物激素与绿色革命”和第479次香山科学会议“植物发育与生殖：前沿科学问题与发展战略”。作为学术秘书申请并组织实施了国家自然科学基金委重大研究计划项目“植物激素作用的分子机理”（2008年－2016年）并在结题验收中获得优秀。
李传友团队长期研究植物系统性防御与可塑性发育的机理与调控。以番茄为模式研究植物利用激素信号控制抗性与其它重要农艺性状形成的分子基础和调控网络，致力于用分子设计手段培育绿色安全、营养健康、美味可口的番茄新品种。在Nature, Nature Plants, PNAS, Molecular Plant, Plant Cell等国际主流学术刊物发表论文120余篇，引用10000余次。在国际权威出版社ELSEVIER出版英文专著«Hormone Metabolism and Signaling in Plants»。H-index为55。 连续多年入选Clarivate Analytics（科睿唯安）全球前1%高被引学者名单。申请PCT 专利1项，获得授权专利20项、植物新品种权2项，育成农业农村部登记番茄品种2个。
KEY PUBLICATIONS (*Corresponding author):
1. An, C., Deng, L., Zhai, H., You, Y., Wu, F., Zhai, Q., Goossens, A., and Li, C.* (2022). Regulation of jasmonate signaling by reversible acetylation of TOPLESS in Arabidopsis. Mol Plant (DOI: 10.1016/j.molp.2022.06.014)
2. Du, M., Daher, F., Liu, Y., Steward, A., Tillmann, M., Zhang, X., Wong, J., Ren, H., Cohen, J., Li, C.*, and Gray, W. * (2022). Biphasic control of cell expansion by auxin coordinates etiolated seedling development. Sci Adv 8: eabj1570.
3. Zhai, Q., Deng, L., and Li, C.* (2020). Mediator subunit MED25: at the nexus of jasmonate signaling. Curr Opin Plant Biol 57: 78–86.
4. Zhai, H., Zhang, X., You, Y., Lin, L., Zhou, W.*, and Li, C.* (2020). SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification. EMBO J 39: e105047.
5. Wu, F., Deng, L., Zhai, Q., Zhao, J., Chen, Q., and Li, C.* (2020). Mediator subunit MED25 couples alternative splicing of JAZ genes with fine-tuning of jasmonate signaling. Plant Cell 32: 429–448.
6. Sun, C., Deng, L., Du, M., Zhao, J., Chen, Q., Huang, T., Jiang, H., Li, C-B.*, and Li, C.* (2020). A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Mol Plant 13: 42–58. (Cover story). Highlighted with a Spotlights article in Molecular Plant, https://doi.org/10.1016/j.molp.2019.12.012
7. Wang, H., Li, S., Li, Y., Xu, Y., Wang, Y., Zhang, R., Sun, W., Chen, Q., Wang, X., Li, C.*, and Zhao, J.* (2019). MED25 connects enhancer-promoter looping and MYC2-dependent activation of jasmonate signaling. Nat Plants 5: 616–625. (Recommended in F1000 Prime)
8. Liu, Y., Du, M., Deng, L., Shen, J., Fang, M., Chen, Q., Lu, Y., Wang, Q.*, Li, C.*, and Zhai Q.* (2019). MYC2 regulates the termination of jasmonate signaling via an autoregulatory negative feedback loop. Plant Cell 31: 106–127. Highlighted with an In Brief article in Plant Cell, https://doi.org/10.1105/tpc.19.00004;
Highlighted with a Spotlight article in Trends Plant Sci., https://doi.org/10.1016/j.tplants.2019.06.001.
9. You Y, Zhai Q*, An C, and Li C.* (2019). LEUNIG_HOMOLOG mediates jasmonate-dependent transcriptional activation in cooperation with the coactivators HAC1 and MED25. Plant Cell 31: 2187–2205.
10. Zhou, W., Lozano-Torres, J.L., Blilou, I., Zhang, X., Zhai, Q., Smant, G., Li, C., and Scheres, B.* (2019). A jasmonate signaling network activates root stem cells and promotes regeneration. Cell 177: 942–956.
11. Zhang, X.，Zhou, W., Chen, Q., Fang, M., Zheng, S., Ben, S., and Li, C.* (2018). The Mediator subunit MED31 is required for radial patterning of Arabidopsis roots. Proc Natl Acad Sci USA 115: E5624–E5633.
12. An, C., Li, L., Zhai, Q.*, You, Y., Deng, L., Wu, F., Chen, R., Jiang, H., Wang, H., Chen, Q., and Li, C.* (2017). Mediator subunit MED25 links the jasmonate receptor to transcriptionally active chromatin. Proc Natl Acad Sci USA 114: E8930–E8939.
13. Du, M., Zhao, J.*, Tzeng, D., Liu, Y., Deng, L., Yang, T., Zhai, Q., Wu, F., Huang, Z., Zhou, M., Wang, Q., Chen, Q., Zhong, S., Li, C-B.*, and Li, C.* (2017). MYC2 orchestrates a hierarchical transcriptional cascade that regulates jasmonate-mediated plant immunity in tomato. Plant Cell 29: 1883–1906.
14. Li J, Li C, and Smith S.M. (Eds.). (2017). Hormone Metabolism and Signaling in Plants. Woodhead Publishing, Elsevier. (Book)
15. Li, C.*, Li, J.*, Harter, K., Lee, Y., Leung, J., Martinoia, E., Matsuoka, M., Offringa, R., Qu, L., Schroeder, J., and Zhao, Y. (2016). Toward a molecular understanding of plant hormone actions. Mol Plant 9: 1–3.
16. Xu, Y., Jin, W., Li, N., Zhang, W., Liu, C., Li, C.*, and Li, Y.* (2016). UBIQUITIN-SPECIFIC PROTEASE14 interacts with ULTRAVIOLET-B INSENSITIVE4 to regulate endoreduplication and cell and organ growth in Arabidopsis. Plant Cell 28: 1200–1214.
17. Zhai, Q., Zhang, X., Wu, F., Feng, H., Deng, L., Xu, L., Zhang, M., Wang, Q.*, and Li, C.* (2015). Transcriptional mechanism of jasmonate receptor COI1-mediated delay of flowering time in Arabidopsis. Plant Cell 27: 2814–2828. (Recommended in F1000 Prime)
18. Du, M., Zhai, Q., Deng, L., Li, S., Li, H., Yan, L., Huang, Z., Wang, B., Jiang, H., Huang, T., Li, C-B., Wei, J., Kang, L., Li, J., and Li, C.* (2014). Closely-related NAC transcription factors of tomato differentially regulate stomatal closure and re-opening during pathogen attack. Plant Cell 26: 3167–3184.
19. Sun, J., Qi, L., Li, Y., Zhai, Q., and Li, C.* (2013). PIF4 and PIF5 link blue light and auxin to regulate the phototropic response in Arabidopsis. Plant Cell 25: 2102–2114.
20. Li, S., Zhao, B., Yuan, D., Duan, M., Qian, Q., Tang, L., Wang, B., Liu, X., Zhang, J., Wang, J., Sun, J., Liu, Z., Feng, Y., Yuan, L.*, and Li, C.*. (2013). The rice zinc finger protein DST enhances grain production through controlling Gn1a/OsCKX2 expression. Proc Natl Acad Sci USA 110: 3167–3172.
21. Yan, L., Zhai, Q., Wei, J., Li, S., Wang, B., Huang, T., Du, M., Sun, J., Kang, L., Li, C-B.*, and Li, C.* (2013). Role of tomato lipoxygenase D in wound-induced jasmonate biosynthesis and plant immunity to insect herbivores. PLoS Genet 9: e1003964.
22. Zhai, Q., Yan, L., Tan, D., Chen, R., Sun, J., Gao, L., Dong, M-Q., Wang, Y., and Li, C.* (2013). Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity. PLoS Genet 9: e1003422.
23. Chen, R., Jiang, H., Li, L., Zhai, Q., Qi, L., Zhou, W., Liu, X., Li, H., Zheng, W., Sun, J., and Li, C.* (2012). The Arabidopsis Mediator subunit MED25 differentially regulates jasmonate and ABA signalings through interacting with MYC2 and ABI5. Plant Cell 24: 2898–2916.
24. The Tomato Genome Consortium. (2012). The tomato genome sequence provides insights into fleshy fruit evolution. Nature 485: 635–641. (Cover story)
25. Sun, J., Qi, L., Li, Y., Chu, J., and Li, C.* (2012). PIF4-mediated activation of YUCCA8 expression integrates temperature into the auxin pathway in regulating Arabidopsis hypocotyl growth. PLoS Genet 8: e1002594. (Recommended in F1000 Prime)
26. Chen, Q., Sun, J., Zhai, Q., Zhou, W., Qi, L., Xu, L., Wang, B., Chen, R., Jiang, H., Qi, J., Li, X., Palme, K., and Li, C.* (2011). The basic helix-loop-helix transcription factor MYC2 directly represses PLETHORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis. Plant Cell 23: 3335–3352. (Recommended in F1000 Prime)
27. Sun, J., Jiang, H., and Li, C.* (2011). Systemin/jasmonate-mediated systemic defense signaling in tomato. Mol Plant 4: 607–615.
28. Zhou, W., Wei, L., Xu, J., Zhai, Q., Jiang, H., Chen, R., Chen, Q., Sun, J., Chu, J., Zhu, L., Liu, C-M., and Li, C.* (2010). Arabidopsis tyrosylprotein sulfotransferase acts in the auxin/PLETHORA pathway in regulating post-embryonic maintenance of root stem cell niche. Plant Cell 22: 3692–3709.
29. Liu, F., Jiang, H., Ye, S., Chen, W-P., Liang, W., Xu, Y., Sun, B., Sun, J., Wang, Q., Cohen, J.D., and Li, C.* (2010). The Arabidopsis P450 protein CYP82C2 modulates jasmonate-induced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis. Cell Res 20: 539–552.
30. Sun, J., Xu, Y., Ye, S., Jiang, H., Chen, Q., Liu, F., Zhou, W., Chen, R., Li, X., Tietz, O., Wu, X., Cohen, J., Palme, K., and Li, C.* (2009). ArabidopsisASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation. Plant Cell 21: 1495–1511.
31. Liang, W., Li, C-B., Liu, F., Jiang, H., Li, S., Sun, J., Wu, X., and Li, C.*. (2009). The Arabidopsis homologs of CCR4-associated factor 1 exhibit mRNA deadenylation activity and play a role in plant defense responses. Cell Res. 19: 307–316.
32. Bu, Q., Jiang, H., Li, C-B., Zhai, Q., Zhang, J., Wu, X., Sun, J., Xie, Q., and Li, C.* (2008). Role of the Arabidopsis thaliana NAC transcription factors ANAC019 and ANAC055 in regulating jasmonic acid-signaled defense responses. Cell Res 18: 756–767.
33. Li, C., Schilmiller, A.L., Liu, G., Lee, G.I., Jayanty, S., Sageman, C., Vrebalov, J., Giovannoni, J.J., Yagi, K., Kobayashi, Y., and Howe, G.A.* (2005). Role of β-oxidation in jasmonate biosynthesis and systemic wound signaling in tomato. Plant Cell 17: 971–986.
34. Li, C., Liu, G., Xu, C., Lee, G., Bauer, P., Ganal, M., Ling, H., and Howe, G.A.* (2003). The tomato Suppressor of prosystemin-mediatedresponse2 gene encodes a fatty acid desaturase required for the biosynthesis of jasmonic acid and the production of a systemic wound signal for defense gene expression. Plant Cell 15: 1646–1661.
35. Li, L.#, Li, C.#, Lee, G.I., and Howe, G.A.* (2002). Distinct roles for jasmonate synthesis and action in the systemic wound response of tomato. Proc Natl Acad Sci USA 99: 6416–6421. (#These authors contributed equally to this work)
联系方式
通讯地址：山东省泰安市岱宗大街61#山东农业大学
联系电话: 13671008032
E-mail: cyli@genetics.ac.cn
联系地址：山东农业大学岱宗校区国重楼223房间
